Abstract
Abstract Diabetes and obesity are thought to be risk factors for colorectal cancer in humans. In our recent study, whole body X-irradiated Otsuka Long-Evans Tokushima Fatty (OLETF) rats, a model animal of type 2 diabetes, developed low incidence of small intestine adenocarcinoma, but not in nondiabetic Long-Evans Tokushima Otsuka (LETO) rats. In the present study, six-week-old male OLETF and LETO rats (n=24) were given weekly s.c. injections of 15 mg/kg azoxymethane (AOM) for three weeks and killed after 30 weeks from the initial treatment. The incidences of ear duct tumors in LETO and OLETF rats were 0% and 67% (P<0.001), respectively. Those of small intestine tumors in these strains were 0% and 43% (P<0.001), respectively, and those of colon tumors were 46% and 79% (P<0.05), respectively. Serum triglyceride and free fatty acid levels in OLETF rats were significantly higher than those in LETO rats at sacrifice, but average serum insulin was lower than that in LETO rats. Fatty change of hepatocytes was common in OLETF rats, but not in LETO rats. Hepatic IGF-1, leptin and PAI-1 mRNA levels were not different in two strains. These data suggest that hyperlipidemia plays an important role in high susceptibility to AOM-induced carcinogenesis in OLETF rats. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 2454.
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