Abstract
Abstract DLEU7 was first identified as a tumor suppressor in B-CLL. We previously showed that Dleu7 functions as a potent NF-kappaB and NFAT inhibitor. To investigate possible function of Dleu7 in brain tumorigenesis we carried out the real-time PCR of RNAs isolated from different parts of human brain, brain tumors and brain tumor cell lines and found that expression of DLEU7 significantly decreased in brain tumor cell lines and brain tumors (glioblastoma) in comparison with normal brain tissues. We further investigated the effect of DLEU7 expression in HTB-15 glioblastoma cell line. Our results showed that Dleu7 overexpression resulted in apoptosis and cell cycle halt. In addition, adenovirus-mediated DLEU7 expression resulted in 100 percent increase of caspase 3/7 activation compared to AdenoGFP control in HTB-15 cells. Our data indicate that DLEU7 may play a tumor suppressor role in glioblastoma. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 2185. doi:10.1158/1538-7445.AM2011-2185
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