Abstract 2179: Relationship between daily habits and risk of death in patients with biliary tract cancer: a large-scale cohort study in Japan

Abstract

Abstract Objective: Biliary tract cancer is one of the deadliest diseases in East Asia. Death due to this disease comprises 5% of total cancer deaths in Japan. This study was conducted to evaluate the relationship between biliary tract cancer and daily habits using data from the Japan Collaborative Cohort Study for Evaluation of Cancer Risk sponsored by the Japanese Ministry of Education (JACC study). Methods: In the JACC study, a cohort of 110,792 subjects aged 40-79 from 19 prefectures in Japan completed the baseline survey during 1988-1990. The subjects were followed up until 2009. The endpoint for the present study was death due to biliary tract cancer, coded as C22.1 (intrahepatic bile duct carcinoma, CCC), C23 (malignant neoplasm of the gallbladder, GB cancer), and C24 (malignant neoplasm of other and unspecified parts of the biliary tract, BD cancer) in the International Classification of Diseases and Related Health Problems, 10th Revision (ICD-10). The hazard ratio (HR) of biliary tract cancer mortality for smoking and drinking habits, high intake of fatty food, body mass index, and the job category (office job, field work, and others) was evaluated. All results were considered to be significant at the 5% critical level. Results: High intake of fatty food, smoking habit, and field work showed a significant positive association with death in female patients due to BD cancer in females [HR = 1.87, 95% confidence interval (CI): 1.03-3.39; HR = 1.56, 95% CI: 1.02-2.39; and HR = 2.23, 95% CI: 1.03-4.84, respectively]. No significant relationship was observed between daily habits and death due to CCC and GB cancer. Conclusion: High intake of fatty food is often a key factor in the risk of death due to biliary tract cancer, and it is well known that smoking can cause various other cancers. Our findings support the results of a previous research. Moreover, our results suggest that occupational differences may have an effect on mortality in female patients with biliary tract cancer. Therefore, a more detailed analysis of the job category is required for a more meaningful interpretation of the data. Citation Format: Shinji Otani, Youichi Kurozawa, Takenobu Hosoda, Haosheng Mu, Kazunari Onishi, Yae Yokoyama, Joji Watanabe, Teruhisa Sakamoto, Kanenori Endo, Masahide Ikeguchi. Relationship between daily habits and risk of death in patients with biliary tract cancer: a large-scale cohort study in Japan. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 2179. doi:10.1158/1538-7445.AM2014-2179