Abstract
Abstract The International Cancer Genome Consortium (ICGC) was established to bring together researchers from around the globe to comprehensively analyze the genomic, transcriptomic, and epigenomic changes in 50 different tumour types or subtypes that are of clinical and societal importance across the globe (International network of cancer genome projects. Nature 464, 993-998 (15 April 2010)). As of October 2012, the ICGC has received commitments from researchers and funding organizations in Asia, Australia, Europe and North America for 47 project teams in 15 jurisdictions to study more than 21,000 tumour genomes. Over 23,000 tumours that meet ICGC requirements for consent have been obtained and over 20,000 samples have been approved by research pathologists as meeting ICGC standards. Raw datasets exist for > 10,000 tumours, including > 1,700 whole genome sequences, > 5,130 exomes, > 9,700 copy number alterations, > 4,900 transcriptomes (RNASeq) and over 6,600 methylomes. Processed data is available via the Data Coordination Centre (http://dcc.icgc.org) based at the Ontario Institute for Cancer Research and is updated bimonthly. The latest data release (Version 10) in October 2012 includes datasets from 33 ICGC members and five additional groups. In total, ICGC data release 10 comprises data from 7,022 cancer genomes. In the next five years, ICGC will deliver on its initial and new objectives, including 1) sequencing a cumulative number of >25,000 tumour genomes from 50 or more tumour types, 2) improving data quality of ICGC datasets; 3) developing a scalable software infrastructure to support data management and cancer genome research; 4) streamlining data access mechanisms to accelerate usage and downstream discoveries without compromising the need to protect patient confidentiality; 5) coordinating cross-tumour analyses; 6) and training basic and clinician scientists to use ICGC datasets and tools. More information can be found on www.icgc.org Citation Format: Thomas J. Hudson, Jennifer L. Jennings. International Cancer Genome Consortium (ICGC). [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr 2004. doi:10.1158/1538-7445.AM2013-2004
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