Abstract 19119: Augmentation Index is Associated With Renal Function in Black but Not in White Young Adults: The Bogalusa Heart Study

Abstract

Background: Increased Augmentation Index (AI) has been associated with kidney damage in patients with hypertension and underlying cardio-metabolic diseases. However, information is scant on the association between AI and renal function/performance in non-institutionalized asymptomatic young adults. Hypothesis: Race-specific differences exist on the association between AI and renal function (as defined by estimated glomerular filtration rate (eGFR)), in asymptomatic young adults. Methods: As a part of the Bogalusa Heart Study, a long term community based study, 884 non-institutionalized participants with a mean age of 43.5 years (29.4-51.3), 68.3% whites and 41.9% male were considered. AI was estimated non-invasively by applanation tonometry of the radial artery. eGFR was calculated using the MDRD study equation. Race-specific independent association of AI with eGFR was tested through multivariable adjusted linear regression analyses. Results: Black participants had higher AI and eGFR levels compared to whites. Of note, black females had significantly higher levels of AI and eGFR compared to black males (p<0.01). No significant sex differences were noted in white participants. In multivariable adjusted linear regression analyses, controlling for age, sex and traditional cardiovascular risk factors, AI was significantly and directly associated with eGFR in blacks (B=1.12, p<0.001), but not in whites (B=0.039, p=0.34) Conclusion: The observed differences in the impact of AI on renal function help support the hypothesis that underlying mechanisms for cardiovascular disease related-end organ damage differ among race groups. Further, this may aid to enhance race-specific approaches on prevention and screening of cardiovascular disease and complications.