Abstract
Central and peripheral vascular damage by oxidative stress-mediated mechanisms has been described in male and female patients with inflammatory pathologies. However, information is scant on the association between oxidative stress and myocardial perfusion in biracial (black-white) asymptomatic young adults. We assessed the hypothesis that the association between oxidative stress and myocardial perfusion differs among biracial (black-white) asymptomatic young adults. As a part of the Bogalusa Heart Study, systemic oxidative stress (in terms of urinary creatinine-indexed levels of 8-epi-PGF2alfa -isoprostane-) and non-invasive myocardial perfusion (in terms or Subendocardial Viability Ratio -SEVR) were assessed in 605 asymptomatic individuals aged 29-51 years (mean 43.4; 68.7% white and 54.4% female), along with evaluation of traditional cardiovascular risk factors. The race-specific association of urinary creatinine -indexed 8-epi-PGF2alfa with SEVR was tested through multivariable- adjusted linear regression analyses. SEVR levels were significantly higher in white and male participants (p<0.001), whereas creatinine-indexed 8-epi-PGF2alfa levels were lower; when compared to their counterparts. In race-specific multivariable-adjusted linear regression analyses, controlling for age, sex, body mass index, smoking, hypertensive and diabetic status; along with traditional cardiovascular risk factors, a significant inverse association was observed between creatinine-indexed 8-epi-PGF2alfa and SEVR in white (B= -0.246, p<0.001) but not in black participants (B= 0.007, p=0.93). In conclusion, the described observations help support the hypothesis that the impact of oxidative stress on myocardial perfusion (coronary microcirculation) is different among race (black-white) groups. Further, this may aid to emphasize and enhance race-specific risk factor screening and disease evaluation.
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