Abstract 18816: Association Between Perceived Exertion Intensity of Physical Activity and Agiographic Score in Patients With Coronary Artery Disease: A Pilot Study

Abstract

The protective role of physical activity on coronary artery disease (CAD) has been demonstrated by many studies. The influence of physical activity intensity on CAD progression is unknown. Purpose: To evaluate the association between physical activity intensity and angiography score. Methods: 94 patients evaluated, 63 patients with known CAD and 31 patients without CAD who had coronary computed tomography angiography. Muscle strength was measured by handgrip. A pedometer was used to quantify steps/day. Physical activity questionnaire was used to determine physical activity in months and intensity was determined by the modified BORG scale (BORG). Gensini score was used to calculate atherosclerotic load. Results: There was no difference between patients with and without CAD for age , systolic blood pressure, diastolic blood pressure, BORG, total steps, and handgrip, respectively. Gensini was higher for patients with CAD than those without CAD [14 (6-24) vs 0 (0-0); p=0.012, respectively. There was a negative correlation between Gensini and week total steps (r=-0.29; p=0.027). Univariate logistic regression model using Gensini>13 as the dependent variable, age (OR, 1.082; 95% CI, 1.012-1.157; p=0.021), moderate-to-high intensity (OR, 0.359; 95% CI, 0.134-0.958; p=0.041), and very vigorous intensity (OR, 4.308; 95% CI, 0.899-20.632; p=0.047) were associated with Gensini, whereas light intensity was not significantly associated with Gensini (OR, 1.218 ; 95% CI, 0.472-3.138; p=0.68). In a multivariate logistic regression model, age (OR, 1.144; 95% CI, 1.039-1.260; p=0.006) and moderate-to-high intensity (OR, 0.316; 95% CI, 0.107-0.931; p=0.037) remained associated with median Gensini>13 adjusted by presence of dyslipidemia, hypertension, diabetes independently, smoking, handgrip strength, week steps, and months of physical activity. Conclusion: our results show that only moderate-to-high intensity of physical activity is independently associated with Gensini score, suggesting a protective effect of intensity from moderate to high on progression of coronary alterations.