Abstract 18411: Dietary Intake of n-3 Long-Chain Polyunsaturated Fatty Acids, Diabetes Mellitus and Risk of Myocardial Infarction in Patients with Suspected Coronary Artery Disease

Abstract

Background: A high intake of n-3 long-chain polyunsaturated fatty acids (LCPUFAs) is usually recommended in secondary prevention of coronary heart disease, particularly in patients with high triglyceride levels. Furthermore, a beneficial effect has been observed in patients with heart failure, who are frequently insulin resistant. Objective: The aim was to study the influence of impaired glucose metabolism and diabetes mellitus on the relation between dietary intake of n-3 LCPUFAs and risk of acute myocardial infarction (AMI) in patients undergoing coronary angiography for suspected coronary artery disease in 2000-2004. Design: This study included 2378 participants of the Western Norway B-Vitamin Intervention Trial (WENBIT). Daily intakes of n-3 LCPUFAs were estimated based on average dietary intakes during the last year as reported in a food-frequency questionnaire at baseline. Hazard ratios (HRs (95% CI)) of AMI (fatal and non-fatal) according to n-3 LCPUFA intake were calculated using Cox-regression adjusted for cardiovascular risk factors by comparing upper vs. lowest tertile and as trend across tertiles. Patients were followed until 31 December 2006. Results: Mean age of the participants was 62 years and 80% were male. Patients were sub-grouped into non-diabetics (HbA1c <5.7%), pre-diabetics (HbA1c ≥5.7%), and diabetics (diagnosed), and were also stratified according to median triglyceride levels. Among patients with diabetes there was a significantly reduced risk of AMI in the upper vs. the lowest tertile of n-3 LCPUFA intake, multivariate HR (95% CIs) 0.34 (0.14, 0.82), P for trend=0.008. In non-diabetic patients with HbA1c <5.7% there was an increased risk of AMI in the upper tertile of n-3 LCPUFA intake, 1.97 (1.05, 3.67), P for trend=0.02. Risk estimates were strengthened in their respective directions in both diabetic and non-diabetic patients with triglyceride levels above median. No risk associations were seen in pre-diabetics. Conclusions: Among patients with established coronary artery disease, a high intake of n-3 LCPUFAs was associated with a reduced risk of AMI in diabetic patients and an increased risk of AMI in non-diabetic patients. The effects were particularly pronounced in those with elevated triglyceride levels.