Abstract
In this study we investigated the oxidative stress, antioxidants and inflammatory molecules in patients of acute myocardial infarction (AMI) with diabetes (n = 50) and non-diabetes (n = 50). Fifty healthy subjects were taken as control. The levels of plasma TBARS and ceruloplasmin levels were significantly high in diabetic and non-diabetic AMI patients as compared with control. On the other hand, the activities of both enzymatic and non-enzymatic antioxidants were significantly decreased in diabetic and non-diabetic AMI patients as compared with control. Inflammatory markers showed significant rise in diabetic patients as compared with controls. Our results show increased inflammation and oxidative stress in patients with AMI, and magnitude of imbalance is greater in diabetic AMI patients, possibly because of greater inflammation in diabetic patients.
Highlights
Diabetes mellitus is a major risk factor for coronary artery disease and is associated with a higher incidence of acute myocardial infarction (AMI) and sudden death
Increased levels of the products of oxidative damage to lipids have been detected in serum of AMI diabetic patients, and their presence correlates with the development of complications[79]
Evidence suggest that antioxidants can give effective protection against free radical production, which is responsible for reperfusion induced damage and lipid per oxidation and it leads to inhibition of thrombosis, myocardial damage and arrhythmias during AMI
Summary
Diabetes mellitus is a major risk factor for coronary artery disease and is associated with a higher incidence of acute myocardial infarction (AMI) and sudden death. There is evidence that antioxidants can protect against free radical defense, which is responsible for reperfusion-induced damage and lipid peroxidation, and may thereby inhibit thrombosis, myocardial damage and arrhythmias during AMI. Increased levels of the products of oxidative damage to lipids have been detected in serum of AMI diabetic patients, and their presence correlates with the development of complications[79]. Evidence suggest that antioxidants can give effective protection against free radical production, which is responsible for reperfusion induced damage and lipid per oxidation and it leads to inhibition of thrombosis, myocardial damage and arrhythmias during AMI.
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