Abstract
Abstract nc886, a novel type of non-coding RNA, was originally recognized as a microRNA precursor (pre-miRNA) or a vault RNA (vtRNA), but it has been shown to be barely processed into mature microRNAs and be mostly dissociated from the vault complex. So far, nc886’s best studied role is as a cellular RNA ligand and regulator of PKR (Protein Kinase RNA-activated). When nc886 is suppressed, PKR is activated and this activation leads to apoptosis through the canonical PKR-eIF2α cell death pathway. Given that the expression of nc886 was found to be suppressed in a variety of cancer cells, nc886/PKR's such role is thought to be critical in eliminating pre-cancerous cells during certain stages of tumorigenesis. Thus, nc886 plays a sentinel role against tumorigenesis by controlling PKR activity in some cells. We have found that nc886 is decreased also in gastric cancer. Our measurement of nc886 in 88 specimens from gastric cancer patients indicates that nc886 tends to be decreased in tumors relative to the adjacent normal tissues. Also, DNA methylation of the nc886 locus exhibits an anti-correlation to nc886 level, and therefore epigenetic silencing is likely to be the mechanism for the decrease of nc886 in gastric cancer. Moreover, hypermethylation of the nc886 promoter region is associated with poor survival of gastric cancer patients. All our data indicates a putative tumor suppressive role for nc886 and the possibility of a clinical application for nc886 as a prognostic marker for gastric cancer. Citation Format: Seon-Young Kim, Jong Lyul Park, Yong Sung Kim, Kwang Soo Lee, Sung Ho Jeon, Yong Sun Lee. nc886, a putative tumor suppressive non-coding RNA in gastric cancer. [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr 1838. doi:10.1158/1538-7445.AM2013-1838
Published Version
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call