Abstract 18290: Enhancing Outcomes in Dyslipidemia Management: Contemporary Insights and Perspectives From the Indian Consensus

Abstract

Introduction: To establish a comprehensive consensus statement on dyslipidemia management, incorporating contemporary evidence and drawing from the valuable real-world experiences of Indian physicians and cardiologists Methods: A virtual collaborative educational initiative was convened in May 2023, through a series of 13 nationwide virtual interactive meetings (n=238) at the forefront of dyslipidemia management (STRATIFY 2 Consensus Group). The cumulative clinical experience was approximately 6,000 man years, who rated their level of agreement for 10 questions with each item on a 5-point Likert scale. This was preceded by a contemporary evidence-based discussion on the updates for dyslipidemia including statins. Weighted mean for the Likert scale was calculated and consensus was pre-defined as a score > 100. GraphPad 9.5.1 and ANOVA were used for statistical analysis. Results: The highest agreement score was for, using LDL-C as a performance measure enhances cholesterol control in high-risk groups, leading to reduced cardiovascular disease morbidity and mortality (119), attainment of LDL-C goals in patients receiving high-intensity statin therapy needs improvement in real-world settings (116), combination of short-term DAPT and intensive rosuvastatin reduces the risk of recurrent stroke (113), validated risk calculators such as QRISK3 are valuable tools for guiding clinical decisions regarding the initiation of statin therapy (112), rosuvastatin 40 mg daily is more effective in reducing LDL-C levels as compared to atorvastatin 80 mg (110), Rosuvastatin is more effective than Atorvastatin in reducing LDL-C levels in diabetes mellitus (104) (Figure). The highest mean response scores (±SD, 95% CI) for consensus were for agree (61±25, 95% CI 44 to 80) followed by strongly agree (32±17, 95% CI 20 to 44) Conclusions: The consensus findings contribute to advancing dyslipidemia management and guiding evidence-based practices for improved patient outcomes.