Abstract 15751: Trends and Disparities in Pulmonary Arterial Hypertension Over the Past Decade: A National Inpatient Sample Database Study

Abstract

Introduction: Pulmonary arterial hypertension (PAH) is well defined, however, the trends and disparities have not been studied recently after the update in guidelines. Methods: We utilized National Inpatient Sample Database 2010-2019 to identify the cohort with principal diagnosis of PAH using ICD-9 and 10 codes. Primary outcome analysis included the crude admission rate of PAH per 1,000,000 adult hospitalizations during each calendar year stratified by sex, race, and median household income (MHOI). Secondary outcome analysis included trends in inpatient mortality rate, mean length of hospital stay (LOS), and mean total hospital charges (THC). Results: There were a total of 341 million admissions from 2010-2019 out of which 0.004% (13644) were adults admitted with principal diagnosis of PAH. There was no significant difference in year on year admissions in the last decade (Figure). Most patients were aged 18-65 when diagnosed (OR 1.73, 95% CI 1.55-1.92). Females were twice as likely to be diagnosed with PAH than males (OR 2.40, 95% CI 2.17-2.64). African Americans (OR 1.35, 95% CI 1.21-1.50) and Asian/Pacific Islander (OR 1.22, 95% CI 1.04-1.42) were at slightly more risk of PAH. There was no significant difference in inpatient mortality among patients with principal diagnosis of PAH over the last decade. Although mortality increased with increasing age (OR 1.29. 95% CI 1.29-3.33 for age > 65) (OR 1.79, 95% CI 1.45-2.77) but did not defer when stratified for gender , race or year. Conclusion: Admissions for principal diagnosis of pulmonary arterial hypertension have remained unchanged over the last decade. Female sex, age and median house hold income is associated with increased risk for PAH.