Abstract 14296: Agatston Aortic Valve Calcium Score and the Prediction of Transcatheter Aortic Valve Replacement Complications: A Systematic Review and Meta-Analysis

Abstract

Introduction: Aortic valve calcium score (AVCS) is used to determine aortic stenosis severity, but whether it affects transcatheter aortic valve replacement (TAVR) complications is not well studied. Methods: We conducted a literature search in PubMed using the key words “Aortic valve”, “Calcium score”, “Aortic stenosis”, “Computed tomography”,” Calcification”, “Calcium”, “TAVR”, “TAVI”, “Outcomes”, “Complications” up to December, 31 st , 2020. Several studies assessed the different factors affecting TAVR outcomes, of these, AVCS was usually found to be one of them. Only a few studies investigated the effect of AVCS on TAVR outcomes. We included studies classifying their patient cohort into high and low AVCS. These studies used the Agatston AVCS derived from non-contrast computed tomography (CT) in patients with native aortic valves and they investigated the TAVR outcomes in both groups. Results: Three studies were included in our meta-analysis with a total number of 1839 patients. Our pooled analysis showed a similar risk of 30-day mortality (low AVCS 2% vs high AVCS 2.5%, P=0.63), Permanent pacemaker implantation (low AVCS 13.3 % vs high AVCS 11.9 %, P=0.73), Stroke (low AVCS 2.54% vs high AVCS 2.3%, P=0.69), and Major vascular complications (low AVCS 7.3% vs high AVCS 5.5%, P=0.60). Conclusion: The severity of Aortic valve calcification calculated by the Agatston AVCS had no impact on 30-day mortality, stroke, major vascular complications, or the need for a permanent pacemaker after TAVR is performed.