Abstract
Abstract Prostate cancer is the most 2ND leading cause of cancer death among men in United States. In metastatic prostate cancer patients, androgen ablation leads to symptomatic improvement and a decrease in serum prostate-specific antigen (PSA), but in almost patients the disease will eventually become refractory to hormone ablation. Previously, it has been published that IL-1β from macrophage regulates AR dependent signal transduction. In the prostate cancer, Bone morphogenetic protein-6 (BMP-6) levels are elevated than normal prostate. BMPs are members of TGF-β super family that regulates bone formation, hematopoiesis and development. BMP-6 is a pleiotropic growth factor with frequently increased levels of expression in the context of loss of its cognate receptors in prostate cancer cells. In this study, we demonstrated that BMP-6 secretion in CaP affects on macrophage cell line, RAW 264.7. Results showed that BMP-6 increased IL-1β levels in the macrophage and the induction is concentration and time dependent. In association with these observations, it is demonstrated that IL-1β expression by BMP-6 is mediated through ALK3, BMPRII and Smad1/4. Taken together, ERK inhibitor and JNK inhibitor may block IL-1β induction by BMP-6 completely in RAW264.7, macrophage cell line. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 1331.
Published Version
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