Abstract
Background: The polygenic risk score for coronary artery disease (CAD PRS) is an emerging CAD risk assessment tool. It is unclear if it improves predictive value for major adverse cardiovascular events (MACE). This study aims to investigate the value of PRS as predictor for MACE. Methods: Patients who had coronary calcium score (CAC) within the Sanford Heart Screening Program were enrolled in the study from 2011-2021. They were genotyped using Illumina Global Screening Array version 1. PRS was calculated using a literature derived list of 180 single nucleotide polymorphisms. Patients were classified into 3 groups based on CAD PRS: high PRS (> 85 th percentile), moderate PRS (15 th to 85 th percentile) or low PRS (<15 th percentile). MACE was defined as the composite of death, myocardial infarction, coronary revascularization and heart failure hospitalization. Results: A total of 1,380 patients with mean age of 57.76± 9.76 were analyzed of which 6.6% had MACE. Chi-square test revealed a significant relationship between PRS (low, moderate, high) and a future MACE event, [X 2 (N=1380) = 9.9,p < .01]. Post-hoc testing showed that those with high PRS(standardized residuals = 3.14, p < .01) were more likely to have a future MACE event than those with a moderate (standardized residuals =1.59, p=.68) or low PRS (standardized residuals =1.11, p = 1) (Figure 1). Conclusions: This study shows that high CAD PRS has an added value in predicting future MACE in general population as represented in our Sanford Heart Screening Program.
Published Version
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