Abstract 13.35 EFFICIENCY OF FIBROCELL AND BONE MARROW OR ADIPOSE- DERIVED STROMAL VASCULAR FRACTION ON SEVERE PATHOLOGIC SCAR FORMATION IN BURN

Abstract

PURPOSE: Severe scar formation in burn cases causes multiple difficulties for practitioner and importantly for patients. Mostly combination therapies were adminstrated for achieving satifactionary improvments. With the introduction of cell therapies in varying medical conditions, the promising results are obtained in the literature. The aim of this study is to investigate the effect of FIBROCELL ® (autologous fibroblast) (Ars Arthro Biotechnology Corp.) and stromal vascular fraction (SVF) (N-BIOTEK Corp) on severe pathologic scar formation in burn patients. METHODS: A total of 7 patients with severe burn scars were enrolled in this study. Patients were divided in two groups, 3 patients were selected for FIBROCELL® group and and 4 patients for SVF group. Two patients were under 18. The Patient and Observer Scar Assemble Scale (POSAS) was used for evaluation. Three injections were performed in every patient. RESULTS: Mean clinical follow up was 13 months. Neck, chest and upper extremities were commonly effected regions. Hot liquid burn was the most frequent etiology. In SVF group, better scar quality was achived compared to FIBROCELL® group. Improvements in scar thickness and pliability were observed in every patient. Less benefit was achived in itching and color parameters. Pain relief was remarkable in SVF group. CONCLUSION: Fibrocell is an autologous fibroblast that promotes collagen and elastin synthesis in connective tissue. However, the stromal vascular fraction contains highly variable promoting cells. This study showed that cell-based therapies especially SVF were effective and benifical in severe burn scars.