Abstract 12891: Outcomes After Heart Failure Hospitalization Among Patients With Myeloproliferative Neoplasms

Abstract

Introduction: Myeloproliferative neoplasms (MPNs) are chronic leukemias associated with increased risk of cardiovascular (CV) events. MPNs most commonly harbor mutations in the JAK2 gene, which has been associated with adverse cardiac remodeling in mouse models of cardiomyopathy and heart failure (HF). Prior studies suggest patients with MPN are at increased risk of HF. However, in-hospital and readmission outcomes of patients with MPN admitted for HF have not been well characterized. Methods: Adult patients admitted with HF from January 2017 to December 2018 MPN were identified using the National Readmission Database. Propensity score matching (PSM) was performed to match 1 MPN for 10 non-MPN controls. Primary outcomes were in-hospital death and 90-day CV-related, HF-related and all-cause readmissions Results: Patient characteristics after PSM are described in Table 1. Patient characteristics were well-balanced between MPN and non-MPN groups after PSM. MPN patients had similar rates of in-hospital mortality but higher rates of bleeding during index hospitalization. MPN patients had increased risk of in-hospital death (OR 1.17, 95% CI 1.00 - 1.35) and 90-day CV-related (HR 1.10, 95% CI 1.02 - 1.18) and all-cause readmissions (HR 1.24, 95% CI 1.17 - 1.31) but not HF-related (HR 1.05, 95% CI 0.97 - 1.14). Conclusions: Among patients hospitalized for HF, MPN was associated with increased risk of in-hospital death, and 90-day CV-related readmissions. Further investigation is needed in order to improve outcomes in patients with MPN and HF.