Abstract 1283: Prevalence of synchronous oligopolyposis in Hispanics with incident colorectal cancer: A population-based analysis

Abstract

Abstract Background: In Puerto Rico (PR), colorectal cancer (CRC) is the 1st cause of cancer death and the 2nd most common cancer among men and women. Familial CRC accounts for 10-15% of all CRCs. Several studies suggest that inheritance has a significant impact in the pathogenesis of up to a third of all CRC cases. Little is known about the prevalence of polyposis syndromes among Hispanics and statistics are needed to quantify disease burden. Aim: To determine the prevalence of oligopolyposis (defined as ≥20 synchronous colorectal adenomas) among Hispanics with incident CRC. Methods: Pathological reports from patients with biopsies positive for CRC from 2007 to 2011 were retrieved from the PR Central Cancer Registry. A total of 4334 pathological reports were initially obtained. After taking into account the inclusion/exclusion criteria, 1685 reports were included in the final analysis. Reports were analyzed by age, gender, stage at diagnosis and colorectal location (proximal vs. distal). Colorectal polyp burden was calculated using pathology reports and normalization of data based on colon segment size (STATA 10.0). Results: A total of 1685 colectomy specimens with colonic adenocarcinoma were analyzed (46.5% were female). The mean patient age was 68 years (SD ± 11) with an age distribution of: <50 (6.3%), 50-64 (30.7%), 65-75 (72.3%), >75 (27.8%). Tumors were classified as Stage 0 (2.9%), Stage I (19.5%), Stage II (32.2%), Stage III (40.3%), and Stage IV (4.93%). The mean number of polyps was 11 (SD ± 9.6) after normalization. 10.2% of CRC patients had oligopolyposis. Most patients with oligopolyposis were >50 years (96.5%), had tumors located in the proximal colon (62.3%), and had an earlier stage at diagnosis (35.9%) compared to patients without oligopolyposis (p<0.001). Conclusion: In our cohort of Hispanics, oligopolyposis was seen in 10% of cases. Our observations suggest that genetic syndromes associated with colorectal polyposis may account for a higher than expected number of CRC cases. Characteristics<20 adenomas n (%)≥20 adenomas n (%)P-valueAge<50100 (6.6)6 (3.5)0.12350-64467 (30.9)50 (29.0)65-75536 (35.5)57 (33.1)>75408 (27.0)59 (34.3)GenderFemale710 (46.9)75 (43.6)0.408Male803 (53.0)97 (56.4)Stage0/I283 (20.7)56 (35.9)<0.001II442 (32.4)47 (30.1)III/IV640 (46.9)53 (34.0)GradeWell276 (21.4)36 (25.2)0.042Moderate942 (72.9)105 (73.4)Poor75 (5.8)2 (1.4)LocationDistal780 (55.5)62 (37.4)<0.001Proximal625 (44.5)104 (62.3) Citation Format: Carlos E. Bertran, Juan M. Marques, Vanessa Mendez, Katerina Freyre, Yaritza Diaz-Algorri, Luis R. Pericchi, Marievelisse Soto, Marcia R. Cruz-Correa. Prevalence of synchronous oligopolyposis in Hispanics with incident colorectal cancer: A population-based analysis. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 1283. doi:10.1158/1538-7445.AM2014-1283