Abstract 12282: Mismanagement of Hypertension: ColausPsycolaus Study

Abstract

Introduction: The importance of genetic factors in management of hypertension in a population setting is unclear. Hypothesis: To identify the clinical and genetic factors associated with poor control of hypertension in the Swiss population. Methods: Data from first (2009-2012) and second (2014-2017) follow-ups of a population-based, prospective study conducted in Lausanne, Switzerland. Management of hypertension was assessed according to the ESC guidelines based on the 140/90 or the 130/80 mm Hg thresholds. Two genetic risk scores for hypertension (18 and 28 SNPs) and 133 individual SNPs related to response to specific antihypertensive drugs were tested. Results: 1073 and 1157 participants of first and second follow-ups were included. The prevalence of controlled participants using the 140/90 threshold was 58.8% and 63.6% in first and second follow-ups, respectively. Using the 130/80 threshold, the prevalence rates were 31.4% and 34.0%, respectively. On multivariable analysis, using the 140/90 threshold, older age was negatively associated to hypertension control. Using the 130/80 threshold, older age and increased BMI were negatively associated while total number of drugs was positively associated with hypertension control. The associations with gender, education, alcohol drinking and antidiabetic drug treatment varied between surveys and thresholds. No consistent associations were found between genetic risk scores and hypertension control for both surveys and both thresholds. Finally, no significant association was found between individual SNPs and hypertension control according to antihypertensive drug used. Conclusions: Control of hypertension is poor in Switzerland, namely among older adults and possibly among overweight or obese subjects. No association between genetic scores or individual SNPs and hypertension control could be found.