Abstract 11882: The Relationship Between Day-to-Day Variability in Home Blood Pressure and Multiple Organ Function

Abstract

Introduction: Blood pressure variability (BPV) is associated with the prognosis of cardiovascular disease. Continuous home BP measurements can be used to assess day-to-day BPV. Day-to-day BPV is associated with poor cognitive function, and the onset and progression of dementia. However, it is not clear how BPV is related to various organs. Hypothesis: Day-to-day BPV is related to various organ functions. Methods: Three hundred sixty-six participants (136 male, mean age: 71±9 years) who were participated in the community-based health checkup survey in Tarumizu city. All participants measured home blood pressure using HEM-9700T (OMRON Healthcare, Kyoto, Japan). Day-to-day variability of systolic blood pressure were evaluated by coefficient of variation (CV) of home systolic blood pressure in morning during one month. CV was categorized into quartiles. NT-pro BNP and high-sensitivity (hs-)troponin T as cardiac biomarkers were measured. Liver stiffness and renal function were evaluated by Fibrous-4 (Fib4) index and estimated glomerular filtration rate (eGFR), respectively. NT-pro BNP and hs-troponin T were divided by median value. Fib4 index greater than 2.67 and eGFR less than 60 mL/min/1.73 m2 were defined as high Fib4 index and high eGFR. Results: Mean CV was 6.0±1.7%. In logistic analysis adjusted age, gender and receiving antihypertensive medication, the odds ratios for high eGFR and high Fib4 index were higher in the higher quartiles, and only the fourth quartile was an independently associated factor. Moreover, for high NT-pro BNP levels, it was an independent factor in all three quartiles of CV. In contrast, for high troponin T levels, no associations were found for all quartiles of CV (Figure). Conclusion: Day-to-day BPV is independently associated with NT-pro BNP, eGFR and Fib4 index, but not with hs-troponin T.