Abstract
TCF7L2 may affect fasting and postprandial hyperglycaemia in carriers of the rs7903146 polymorphism due to its crucial role in hepatic glucose production. Metformin functions by reducing hepatic glucose production while simultaneously increasing peripheral glucose uptake. Thus the intensity of response under application of metformin may depend on the presence of TCF7L2 gene polymorphism. The aim was to analyze the association between rs7903146 polymorphism of the TCF7L2 gene and acute metformin glycaemic response in patient with newly diagnosed type 2 diabetes (T2D) measured by continuous glucose monitoring (CGM).
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