Abstract
Introduction: Post-acute sequelae of SARS-CoV-2 cardiovascular syndrome (PASC-CVS) is a heterogeneous disorder of post-COVID syndrome that involves a wide range of cardiovascular symptoms including palpitations, chest pain, dyspnea and dizziness. The clinical time-course of PASC-CVS is not well characterized. We sought to understand predictors of time to symptom improvement for patients with PASC-CVS. Methods: Patients with PASC-CVS undergoing evaluation in a dedicated post-COVID cardiology clinic were recruited after informed consent. Information was obtained from chart review and included demographics, comorbidities, symptoms, time of infection to time of presentation to the clinic and time to improvement in symptoms. A multivariate linear regression model was used to determine predictors of time to improvement. Results: A total of 144 consecutive patients were included that had complete records available for review. Average age was 46 years, 74% were female and 94% were Caucasian. Comorbities included obesity (49%), mental health disorder (25%), hypertension (24%), hyperlipidemia (24%), pulmonary disease (18%), type II diabetes (9%), atrial arrhythmia (5%) and coronary artery disease (3%). Time from infection to presentation (p <0.001), chest pain (p 0.002) and dyspnea (<0.001) demonstrated significant associations with time to improvement of symptoms and were used in the multivariate regression model (F 27.8, p<0.001). The time to presentation predicted the longest time to symptom improvement, followed by dyspnea, chest pain, and dizziness. Conclusions: This analysis of a large group of PASC-CVS patients suggests those who wait longer to seek care for PASC-CVS symptoms may have longer duration of post-COVID symptoms. Additionally, specific symptoms may take longer to improve than others. Patients with PASC-CVS should therefore consider early medical care to mitigate symptoms and reduce duration of post-COVID syndrome.
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