Abstract
Background: Cardiometabolic risk factors including, obesity, diabetes and hyperlipidemia contribute to increased cardiovascular disease (CVD). While platelets are involved in the pathogenesis of CVD, the relationship between risk factor burden on platelet indices remains uncertain. Indices of platelet size and immaturity can serve as surrogates for platelet hyperreactivity. Hypothesis: We hypothesized that greater cardiometabolic risk factor burden is associated with increased markers of platelet immaturity and platelet size. Methods: Blood was collected from CVD-free adults and platelet parameters including platelet count, mean platelet volume (MPV), percent immature platelet fraction (IPF), and absolute immature platelet fraction (AIPF) measured by CBC. Participants were stratified by number of cardiometabolic risk factors (diabetes, obesity (BMI >=30 mg/kg 2 ), hyperlipidemia (LDL >=130 mg/dL))We calculated median (IQR) values of platelet indices across categories of risk factor burden. We calculated a p-for-trend across risk factor groups via linear regression. Results: Among 141 participants, the mean age was 50.5 ± 14.8 years, 42% were male, 26% Black, 18% Hispanic, 50% had diabetes, 35% obesity and 53% hyperlipidemia. Overall, 14%, 48%, 28%, and 11% had 0, 1, 2 and 3 risk factors, respectively. No association was found between platelet count and risk factor burden. In contrast, risk factor burden was associated with increasing platelet size (p-for-trend 0.0047), percent IPF (p-for-trend 0.0086), and AIPF (p-for-trend 0.0005; Table ). Conclusions: Greater cardiometabolic risk factor burden is associated with increased platelet size and immaturity. These findings offer insight into potential mechanisms linking risk factor burden with CVD.
Published Version
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