Abstract 10116: Sex and Race Disparities in Mitral Regurgitation Related Mortality Rates Among Older Adults; Data from CDC Wonder 1999-2019

Abstract

Mitral regurgitation (MR) is the second most common valvular heart disease in the United States with recent improvements in the management of MR including percutaneous therapies. However, MR-related mortality may vary across sex and race groups in the elderly population. Methods: We used CDC Wide-ranging Online Data for Epidemiologic Research (CDC WONDER) to access National Vital Statistics System data from 1999 to 2019. MR related deaths, age ≥75 years were identified from multiple causes of death and were represented as age-adjusted mortality rates (AAMR) per 100,000 population. Joinpoint regression was used to examine changes in trend and annual percentage change (APC) overall and stratified by sex and race groups. Results: AAMR related to MR decreased from 29.0 in 1999 to 15.4 in 2012 and then increased to 16.4 in 2019 (2012-2019 APC 1.2 [95% CI, 0.5 to 2.0]). AAMR was higher in women (19.6) compared with men (18.6). Among the race groups, AAMR was highest in non-Hispanic whites (NHWs) (20.8) followed by non-Hispanics Others (NH Others) (includes American Indian or Alaska Natives and Asian or Pacific Islanders) (12.7), non-Hispanic blacks (NHBs) (10.5) and lastly Hispanics (10.1). AAMR was highest in NHW females (21.1). After an initial decline, APC in AAMR increased in both men (1.4) and women (1.0) since 2012 and NHWs (0.9) since 2011. AAMR decreased in NHBs (APC -5.0) till 2009 and Hispanics (APC -4.6) until 2013 and remained stable thereafter. APC in AAMR decreased in NH-Others (-1.9) during the entire study period. Conclusion: After initial decline, MR related mortality has been increasing recently. Significant disparities exist across various sex and race subgroups. Further studies are needed to understand these trends and address the underlying causes of the disparities and increasing mortality in this patient population.