Abstract 10104: Sex and Ethnic Disparities in Heart Failure-Related Mortality Rates Among the Young

Abstract

Introduction: Heart failure (HF) accounts for significant morbidity, mortality, and economic suffering. The aim of this study was to examine the trends in HF-related deaths among the young population in the United States from 1999 to 2019. Methods: We used the CDC Wide-ranging Online Data for Epidemiologic Research (CDC WONDER) to access National Vital Statistics System data from 1999 to 2019. HF-related deaths among individuals aged 15-44 years were identified from multiple causes of death and were represented as age-adjusted mortality rates (AAMR) per 100,000 population. Joinpoint regression was used to examine changes in trends and annual percentage change (APC) overall, and then stratified by sex and ethnicity. Results: Overall, AAMR related to HF remained stable from 1999(2.36) to 2012(2.23) (APC -0.3[95% CI, -0.8 to 0.2]) and then gradually increased until 2019(3.16) (APC 5.0[95% CI, 3.6 to 6.3]). AAMR was higher in men (3.04) than women (1.87). AAMR was highest in non-Hispanic Black (NHB) (6.77) followed by Hispanic (1.51), non-Hispanic White (NHW) (1.91) and lastly non-Hispanic Asian or Pacific Islander (NH-API) (1.11) ethnic groups. After initial decline, APC in AAMR increased in women (5.2) starting in 2012. AAMR did not change significantly in men from 2005 to 2011 and subsequently increased from 2011 to 2019 (APC 4.9). After initially remaining stable, AAMR increased among NHW (APC 4.6) and NHB (APC 4.3) persons from 2012 to 2019. After initial decline, APC in AAMR increased among Hispanic persons (7.2) from 2012 to 2019. APC in AAMR increased in NH-API persons (2.4) during the entire study period (Figure). Conclusion: HF-related mortality in young adults has increased over the last decade. Stratification by sex and ethnicity reveals significant disparities. Mortality in NHBs has been growing at a faster rate than any of the other groups and the gap between mortality in NHBs and NHWs is large and widening.