Abstract
Alloxanic acid ( 3) was resolved by means of brucine and converted into its enantiomorphic esters 8 and amides 9; ethyl (−)-alloxanate whose absolute ( S)-configuration was established by X-ray analysis served as configurational standard for the correlation of (+)-( R)-( 3) and its precursor (−)-( S)-5-hydroxyisourate ( 2), the key uricolytic intermediate.
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