Absence of Sister Chromatid Exchange and Chromosome Aberrations in Mice After in vivo Exposure of Centchroman-a New Non-steroidal Oral Contraceptive.

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Centchroman (3, 4-trans-2, 2-dimethyl-3-phenyl-4p (β-pyrrolidinoethoxy phenyl)-7-methoxy chroman), a non-steroidal oral contraceptive has been developed by the Central Drug Research Institute, Lucknow India. Sister chromatid exchange (SE) and chromosome aberrations (CA) was carried out after in vivo exposure of centchroman in bone marrow cells of female mice. No significant changes of either SCE or CA were observed when the treated groups were compared with solvent controls. Trend tests for the evidence of dose response effects were also insignificant. This indicate that centchroman was not genotoxic in bone marrow cells of mice.