Abstract
Background: ABO blood group distribution defers with racial and geographic variations. They are related to diseases like cardiovascular diseases, cerebral thromboembolism. ABO blood group system may influence coagulation factor VIII which may increase the future risk of thrombosis. Aim: To assess the relation of ABO blood group with coagulation factor VIII in healthy adults. Material and Methods: A prospective type of analytical cross-sectional study was conducted in the Department of Physiology, Dhaka Medical College, Dhaka from July 2019 to June 2020. After obtaining ethical clearance, a total of 190 healthy adults were selected from different areas of Dhaka city based on inclusion and exclusion criteria, with ages ranging from 18 - 45 years. The subjects were interviewed and detailed history regarding personal, family, medical and drug were taken. Prior to sample collection, informed written consent was taken from the participants. Individuals of blood group A were selected as group A, blood group B as group B, blood group AB as group AB and blood group O as group O. Coagulation factor VIII was measured in the Department of Hematology and BMT Unit, Dhaka Medical College Hospital, Dhaka. Blood grouping was done in the Department of Physiology, Dhaka Medical College, Dhaka. Statistical Analysis: For statistical analysis, ONE way ANOVA followed by Bonferroni test were considered using SPSS 25.0 version. Results: In this study, blood group B was most common (33.2%). Coagulation factor VIII was significantly higher (p < 0.001) in blood group A (105.76% ± 11.82%), B (112.00% ± 15.02%), AB (109.80% ± 11.93%) than blood group O (82.00% ± 12.86%). No significant difference was observed among A, B and AB blood groups regarding coagulation factor VIII. Conclusions: It can be concluded that blood group A, B, AB individuals may have more chance of thrombosis due to significantly higher coagulation factor VIII than blood group O individuals.
Highlights
ABO blood group was discovered by Karl Landsteiner in 1900
ABO blood group system may influence coagulation factor VIII which may increase the future risk of thrombosis
ABO blood groups revealed that group B was predominant with 33.2%, followed by group O with 27.4%, group A with 23.7% and
Summary
ABO blood group was discovered by Karl Landsteiner in 1900. It was the landmark for the modern practice of transfusion medicine [1]. Among non-O individuals, the AB group has the highest von Willebrand factor level, followed by blood group B and A individuals. Individuals with non-O blood groups show a significantly higher risk of thrombosis than blood group O due to increased von Willebrand factor and factor VIII [9]. Some studies have shown the influence of ABO blood groups on plasma coagulation factor VIII in different populations They found that mean factor VIII level was significantly higher in blood group A, B and AB than blood group O individuals [11] [12] [13]. Ohira et al (2007) carried out a study on ABO blood groups and the incidence of Venous Thromboembolism (VTE) They showed factor VIII was significantly higher in patients with VTE than participants free from VTE. This study aimed to bring awareness to prevent thrombotic diseases related morbidity
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