ABO blood group does not influence Child-Pugh A cirrhosis outcome: An observational studyfrom CIRRAL and ANRS CO12 CIRVIR cohorts.

Abstract

Non-O blood group promotes deep vein thrombosis and liver fibrosis in both general population and hepatitis C. We aimed to evaluate the influence of Non-O group on the outcome of Child-Pugh A cirrhotic patients. We used two prospective cohorts of Child-Pugh A cirrhosis due to either alcohol or viral hepatitis. Primary end point was the cumulated incidence of 'Decompensation' at 3years, defined as the occurrence of ascites , hydrothorax, encephalopathy, gastrointestinal bleeding related to portal hypertension, or bilirubin >45μmol/L. Secondary end points were the cumulated incidences of (1) 'Disease Progression' including a « decompensation» or « the occurrence of one or more parameters » among: prothrombin time (PT) <45%, albumin <28g/L, Child-Pugh worsening (B or C vs A or B, C vs B), hepatorenal syndrome, and hepato-pulmonary syndrome, (2) other events such as non-malignant portal vein thrombosis (nmPVT), and (3) overall survival. Patients (n=1789; 59.9% Non-O group; 40.1% group O) were followed during a median of 65.4months. At 3years cumulated incidence of Decompensation was 8.3% in Non-O group and 7.2% in group O (P=.27). Cumulated incidence ofDisease Progressionwas 20.7% in Non-O group and 18.9% in group O (P=.26). Cumulated incidence of nmPVT was 2.7% in Non-O group and 2.8% in group O (P=.05). At 3years overall survival was 92.4% in Non-O group and 93.4% in group O (P=1). Non-O group does not influence disease outcome in Child-Pugh A cirrhotic patients. Clinicals trial number NCT03342170.