Abstract
Clinical manifestations of cardiomyopathy include electrical dysfunction (arrhythmias) [1] or mechanical dysfunction (heart failure) [2], or both. In most cases, the etiology of cardiomyopathy is unknown. We have previously reported on skeletal muscle histologic and biochemical abnormalities in young patients with cardiomyopathy without heart failure who presented with uncommon arrhythmias and subtle signs of myocardial mechanical dysfunction [3]. In this report, we evaluate skeletal and cardiac muscle histology and serum and skeletal muscle carnitine concentration in 18 young patients with cardiomyopathy: 10 patients presenting with symptomatic ventricular tachycardia (VT) and 8 patients presenting with symptoms of congestive heart failure (CHF).
Published Version
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