Abstract
Background Neuroinflammation is implicated in the development of chronic neurodegenerative diseases in aging population, including postoperative cognitive dysfunction(POCD), Azheimer′s disease (AD), Parkinson′s disease(PD), and so on. The exact mechanisms, however, remain unclear. Objective To review the altered neuroinflammation and microglia activation in the aging brain. Content The activation of microglia appears in the aging brain, showing neuroinflammation, POCD, and neurodegeneration. The phenomenon is related to age-associated priming of microglia which increases its vulnerability and damages its function. Trend Suppressing microglia activation is one of the promising strategies to combat age-related neurodegenerative diseases. Key words: Aging; Brain; Microglia; Neurodegeneration
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