Abnormal Liver Function in Relation to Hemodynamic Profile in Heart Failure Patients

Abstract

Background We studied the relation between liver function abnormalities and hemodynamic profile in patients with heart failure (HF). Methods and Results In 323 HF patients, liver function was determined by aspartate and alanine aminotransferase (AST, ALT), alkaline phosphatase, γ-glutamyl transpeptidase (GGT), lactate dehydrogenase, and direct and total bilirubin (Bili dir, Bili tot). Central venous pressure (CVP) and cardiac index (CI) were determined invasively. Follow-up consisted of time to all-cause mortality. Mean age was 53 ± 15 years, and 60% were male. In multivariable analysis, all liver function tests related to CVP, but higher CVP was predominantly related to GGT ( r = 0.336, P < .001) and Bili dir ( r = 0.370, P < .001). Only elevated AST ( r =−0.177, P < .01), ALT ( r = −0.130, P < .05), and Bili tot ( r = −0.158, P < .01) were associated with both low CI and elevated CVP. The prognostic value of abnormal liver function tests was related to their interaction with CI and CVP. Conclusions Elevated liver function tests mainly indicate higher CVP, whereas only the presence of elevated AST, ALT, or Bili dir may indicate a low CI. The absence of prognostic information in the presence of invasive hemodynamic measurements suggests that abnormal liver function tests in HF reflect a poor hemodynamic status.