Abstract
The serum of patients with liver cirrhosis inhibits glucose utilization in rat diaphragm. Inhibition is not caused by increased glycogenolysis or decreased glycogen synthesis. Lactate production and fructose utilization are not changed, indicating that the inhibition of glucose utilization is localized at the level of transmembrane transport of glucose or at the level of hexose phosphates. The inhibitory activity of cirrhotic serum, fractioned by gel filtration moves with peptides and aminoacids, excluding the significance of FFA and of growth hormone.
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