Abstract
an Iranian 1000-bed hospital and to assess the activity of commonly used antibiotics including nitrofuantoin against VRE isolates. Methods: This study was carried out between April 2002 and April 2006 in Milad Hospital of Tehran a 1000-bed nonteaching hospital Only patients who had puria and significant bactteriuria included in our study. All isolates performed identification to species level by using routine bacteriological methods and susceptibility testing performed by disk diffusion method as recommended by Clinical Laboratory Institute Standards (CLSI) Results: All urine isolates were also tested for resistance to ampicillin, penicillin, ciprofloxacin, erythromycin, tetracycline and norfloxacine. Results: In Total 837 Enterococcus species were isolated from UTI that 668 (79.8%) and 169 (20.2%) isolates were E.faecalis and E.faecium respectively. Analysis of the collected data revealed that 9.43% vancomycin resistant strains were resistant to nitrofurantoin as well (6 out of 65), while 84.9% of the isolated entrococci (54 out 65) were vancomycin resistant and nitrofurantoin sensitive resistance among E.faecium were prevalent in comparison with E. feaclis isolates Study on the data also showed both vancomycin and nitrofurantoin resistant isolate have higher frequency rate in admitted patients compared with out-patients. Conclusion: It is concluded that susceptibility approximately 85% VRE to nitroforantoin still is the suitable alternative drug for treatment urinary tract infections caused by VRE.
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