Abstract
BackgroundThe genus Salvia is a rich source of structurally diverse terpenoids. Different species of the Salvia have been used in folk medicine of Iran and therefore attracted the attention of researchers for exploring their chemical constituents. In a project directed at structurally interesting bioactive metabolites from Iranian Lamiaceae, we studied Salvia rhytidea.ResultsFractionation of the petroleum ether extract of the root of S. rhytidea led to the isolation of a new 20-nor-abietane diterpenoid (1), together with seven known compounds, comprising five abietane diterpenoids (2–6), and two rearranged abietanes (7, 8). Their structures were established by a combination of 1D and 2D NMR.ConclusionsOur results showed that the root of S. rhytidea could be considered as a new and rich source of different types of abietane and rearranged abietane diterpenoids.
Highlights
ResultsFractionation of the petroleum ether extract of the root of S. rhytidea led to the isolation of a new 20-norabietane diterpenoid (1), together with seven known compounds, comprising five abietane diterpenoids (2–6), and two rearranged abietanes (7, 8)
The genus Salvia is a rich source of structurally diverse terpenoids (Kintzios 2000; Moridi Farimani et al 2013)
The genus Salvia is represented in the Iranian flora by 61 species, of which 17 are endemic (Jamzad et al 2012)
Summary
Fractionation of the petroleum ether extract of the root of S. rhytidea led to the isolation of a new 20-norabietane diterpenoid (1), together with seven known compounds, comprising five abietane diterpenoids (2–6), and two rearranged abietanes (7, 8). Their structures were established by a combination of 1D and 2D NMR
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