Abstract
OBJECTIVES:The purpose of this study was to evaluate the relationship between the serum levels of calcitonin gene-related peptide (CGRP) and the prognosis of pediatric patients with severe pneumonia.METHODS:Children diagnosed with severe pneumonia (n=76) were stratified into the survival (n=58) and non-survival groups (n=18) according to their 28-day survival status and into the non-risk (n=51), risk (n=17) and high-risk (n=8) categories based on the pediatric critical illness score (PCIS). Demographic data and laboratory results were collected. Serum CGRP levels were determined by enzyme-linked immunosorbent assay (ELISA). A receiver operating characteristic (ROC) curve was generated to determine the cutoff score for high CGRP levels.RESULTS:Serum CGRP levels were significantly higher in the survival group than in the non-survival group and were significantly higher in the non-risk group than in the risk and high-risk groups. The ROC curve for the prognostic potential of CGRP yielded a significant area under the curve (AUC) value with considerable sensitivity and specificity.CONCLUSION:Our findings show that CGRP downregulation might be a diagnostic marker that predicts the prognosis and survival of children with severe pneumonia.
Highlights
Respiratory tract infections play an important role in pediatric diseases, result in serious illness, and have a high incidence rate [1]
’ RESULTS calcitonin gene-related peptide (CGRP) was highly expressed in the survival group
A few prognostic biomarkers that appear after the onset of severe pneumonia have been reported
Summary
Respiratory tract infections play an important role in pediatric diseases, result in serious illness, and have a high incidence rate [1]. With continuous improvements in living conditions, health care awareness, and medical and health conditions, the incidence of infectious diseases in infants and young children continues to decline. Respiratory infection is still the most common disease in children [2]. Pneumonia remains the leading cause of death among children in China. Children are more prone to infectious respiratory diseases because of the anatomical and physiological characteristics of the respiratory system in early childhood. Respiratory infection causes mucus obstruction, leading to interstitial pneumonia, emphysema, atelectasis
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