Abstract
Aberrant DNA methylation is a hallmark of acute myeloid leukemia (AML). Various studies showed that t(8;21) AML presented a distinct DNA methylation profile and could be categorized into a separate cluster according to DNA methylation sequencing. Yet, there is still a lack of understanding regarding the causes and mechanisms of this phenomenon. Knowing how the DNA methylation is regulated in t(8;21) AML would enhance our understanding of leukemogenesis and may assist clinical decision-making regarding DNA methylation-targeted therapy. Herein, we summarized our current knowledge concerning DNA methylation regulation in t(8;21) AML and discussed their potential clinical significance in this article.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.