Abstract
Alternative splicing is critical for human gene expression regulation, which plays a determined role in expanding the diversity of functional proteins. Importantly, alternative splicing is a hallmark of cancer and a potential target for cancer therapeutics. Based on the statistical data, breast cancer is one of the top leading causes of cancer-related deaths in women worldwide. Strikingly, alternative splicing is closely associated with breast cancer development. Here, we seek to provide a general review of the relationship between alternative splicing and breast cancer. We introduce the process of alternative splicing and its regulatory role in cancers. In addition, we highlight the functions of aberrant alternative splicing and mutations of splicing factors in breast cancer progression. Moreover, we discuss the role of alternative splicing in cancer drug resistance and the potential of being targets for cancer therapeutics.
Highlights
Edited by Zefeng WangAlternative splicing is critical for human gene expression regulation, which plays a determined role in expanding the diversity of functional proteins
RNA splicing is a form of RNA processing in which a newly made precursor messenger RNA transcript is transformed into a mature messenger RNA and pre-mRNAs become mature mRNAs via the excision of introns and ligation of exons during this process (Ladomery, 2013)
We introduce the process of alternative splicing and its regulatory role in cancers
Summary
Alternative splicing is critical for human gene expression regulation, which plays a determined role in expanding the diversity of functional proteins. Alternative splicing is a hallmark of cancer and a potential target for cancer therapeutics. Based on the statistical data, breast cancer is one of the top leading causes of cancer-related deaths in women worldwide. Alternative splicing is closely associated with breast cancer development. We seek to provide a general review of the relationship between alternative splicing and breast cancer. We introduce the process of alternative splicing and its regulatory role in cancers. We highlight the functions of aberrant alternative splicing and mutations of splicing factors in breast cancer progression. We discuss the role of alternative splicing in cancer drug resistance and the potential of being targets for cancer therapeutics
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