Abstract
Background The purpose of this study was to assess cadaveric proximal femurs from the points of view of bone microarchitecture using ultra-high field (UHF) 7 Tesla magnetic resonance imaging (MRI), bone strength using biomechanical tests and bone mineral density (BMD) using Dual-energy X-ray absorptiometry (DXA). Objectives We aimed at determining whether bone microarchitecture parameters were related to bone strength and BMD and whether UHF MRI can provide additional information regarding bone strength. Methods BMD of ten proximal femurs from five cadavers were investigated using DXA and the bone volume fraction (BVF), trabecular thickness (Tb.Th), and trabecular spacing (Tb.Sp), fractal dimension (FD), Euler characteristics (Euler Ch.), Connectivity density (Conn. D) and Degree of anisotropy (DA) of each femur was quantified using UHF MRI. The whole set of specimens underwent mechanical compression tests to failure. Results BMD and all the microarchitecture parameters except ConnD were significantly correlated with failure load (p Overall, femur bone microarchitecture assessed with UHF MRI was significantly correlated with biomechanical parameters. The multimodal assessment of BMD and trabecular bone microarchitecture using UHF MRI improved the fracture risk prediction of femoral bone and might be of interest for the future investigation of selected osteoporotic patients. Conclusion We demonstrated that femur bone microarchitecture assessed with UHF MRI was significantly correlated with biomechanical parameters. The multimodal assessment of bone mineral density and trabecular bone microarchitecture using UHF MRI improved the fracture risk prediction of femoral bone and might be of interest for the future investigation of selected osteoporotic patients. Disclosure of Interests None declared
Published Version (
Free)
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call