AB1117 DIAGNOSTIC VALUE OF ANTI-CYCLIC CITRULLINATED PEPTIDE ANTIBODIES FOR JUVENILE IDIOPATHIC ARTHRITIS IN KOREA

Abstract

<h3>Background</h3> Anti-cyclic citrullinated peptide(CCP) antibodies are considered to have specificity for rheumatoid arthritis(RA). However, the diagnostic value of anti-CCP antibody has not been proved in juvenile idiopathic arthritis(JIA). <h3>Objectives</h3> The purpose of this study was to access the prevalence of anti-CCP antibodies in Korean children with JIA, and to investigate the diagnostic accuracy of anti-CCP antibodies according to JIA subgroup. <h3>Methods</h3> JIA patients were recruited from Severance Children’s Hospital, Seoul, Korea from 2004 to 2018. Diagnosis of JIA was made by pediatricians according to the International League of Associations for Rheumatology (ILAR) classification. Control group consisted of healthy children with anti-CCP antibodies test, who had visited the outpatient clinic of the hospital for JIA suspected symptoms, but diagnosed as not JIA. Enzyme-linked immunosorbent assay (ELISA) was used for detection and quantification of anti-CCP antibodies. <h3>Results</h3> Study subjects included 295 JIA patients and 165 controls. Among the JIA children, 14 (8.6%) patients were found to be positive for anti-CCP antibodies. 1 (0.6%) of the control group was positive for anti-CCP antibodies. The positive rates of anti-CCP were highest in rheumatoid factor (RF)-positive polyarticular JIA (n=8, 66.7%), followed by systemic JIA (n=3, 3.4%) and oligoarticular JIA (n=3, 2.2%). The sensitivity and specificity of anti-CCP antibodies in all JIA patients was 4.7% and 99.4%. <h3>Conclusion</h3> Anti-CCP antibodies have high specificity for JIA, but its sensitivity is low. Therefore, it can provide additional help for diagnosis of JIA with its high specificity. In particular, anti-CCP antibodies have the highest sensitivity in RF-positive polyarticular JIA than other subgroups, so it can be a more effective diagnostic tool in the subtype. <h3>References</h3> [1] Ferucci ED, Majka DS, Parrish LA, et al. Antibodies against cyclic citrullinated peptide are associated with HLA-DR4 in simplex and multiplex polyarticular-onset juvenile rheumatoid arthritis. Arthritis Rheum 2005; 52:239. [2] Hamooda M, Fouad H, Galal N, et al. Anti-cyclic citrullinated peptide antibodies in children with Juvenile Idiopathic Arthritis. Electron Physician 2016; 8:2897. [3] Petty RE, Laxer RM, Wedderburn LR. Juvenile idiopathic arthritis. In : Petty RE, Laxer RM, Lindsley CB, Wedderburn LR. Textbook of Pediatric Rheumatology. 7th ed. Phliladelphia: W.B Saunders, 2016:188-204. <h3>Disclosure of Interests</h3> None declared