AB0878 CARDIOVASCULAR GOUT

Abstract

Background Gout is characterized by clinical heterogeneity and associated with multicomorbidity. In clinical practice, we can highlight a group of patients suffering from cardiovascular diseases (CVD) and requiring constant medication, in which the gout joins later. Objectives To study the group of patients with gout developing on the basis of pre-existing CVD at the gout onset. Methods 240 patients from our Center database with confirmed gout were included in our study. Comorbidities were registered before the gout onset, at its appearance. The study group consisted of 140 patients with CVD: hypertension with duration for > 5 years and treated by medication, CHD, atrial fibrillation, CHF and stroke. The comparison group consisted of patients with gout, but without CVD (n=100). Results Among patients with pre-existing CVD, the gout debuted later, at the age of 60 (55-65) years (p 0.05). The number of patients having a concentration of uric acid (UA) in blood > 360 mkmol/l and > 480 mkmol/l was similar in the both study and comparison groups (p > 0.05). At the same time, the cases of UA > 600 mkmol/l were higher in study group by 13.1% (OR=1.86; 95%CI 1.50-2 .38; χ2= 5.94, p = 0.015). Conclusion Among our patients, the gout developing on the basis of pre-existing CVD is one of the variant of a debuting gout. The group of patients with so called “cardiovascular gout” is characterized by later gout onset, comorbidities typical for CVD, prevalence of medication (low-dose aspirin, diuretic) and renal mechanisms-triggers of gout. In these patients, the maximal concentration of UA in blood (> 600 mkmol/l) was registered more frequently than in patients with primary gout. Disclosure of Interests None declared