AB0071 RELATIONSHIP BETWEEN PRO-INFLAMMATORY CYTOKINE AND ATHEROGENIC INDEXES IN AXIAL RADIOGRAPHIC SPONDYLOARTHRITIS

Abstract

Background:The cardiovascular burden in inflammatory rheumatic diseases is well recognized. This burden has been reported in spondyloarthritis. Atherogenic indexes are known with their role of predicting cardiovascular risk.Objectives:The aim of our study was to determine the relation between pro-inflammatory cytokines and atherogenic indexes in spondyloarthritis.Methods:We performed a cross sectional study including 38 patients with spondyloarthritis according to ASAS criteria. For each patient we measured interleukin (IL)1, IL6, IL17, IL23 and tumor necrosis factor (TNF) alpha, total Cholesterol (CT), Triglycerides (TG), High density lipoprotein Cholesterol (HDLc) and Low density lipoprotein cholesterol (LDLc). We also calculated the following ratios: CT/HDLc, TG/HDLc, LDLc/HDLc, and LogTG/HDLc.Disease activity was measured using ASDAS (Ankylosing Spondylitis Disease Activity Score) and BASDAI (Bath Ankylosing Spondylitis Disease Activity Index).Statistical analysis was performed using IBM SPSS Statistics 25.Results:The mean age were 45.4±12.5 years. There were 33 Male (sex ratio were 6.6).The mean C-reactive protein(CRP) were 29.6 ±40.34mg/L, mean erythrocyte sedimentation rate(ESR) were 41±33.9mm.The mean ASDASCRP, BASDAI were 2.8±1.24, 3.7±2.12, respectively.Active disease were noted in 68 % of patients using ASDASCRP score.The mean IL1, IL6, IL17, IL23, TNF alpha were 11.6 ±25pg/ml, 15.4±45.9pg/ml, 84.6±77.9pg/ml, 15.3±15.26pg/ml, 25.3± 47.9pg/ml respectively.The mean CT,HDLc,LDLc, TG were 4.47±0.93mmol/l, 1.09±0.3mmol/L, 2.77±0.78mmol/L, 1.29±0.54mmol/L respectively.The mean CT/HDLc, TG/HDLc, LDL/HDLc, LogTG/HDLc were 4.28±1.26, 1.22±0.6, 2.7±1.06, 0.03±0.23, respectively.Correlations were found between TG/HDLC ratio and IL1 (p<0.01, r=0.515), IL6(p<0.05; r=0.407), Log TG/HDLc and IL1 (p< 0.05, r=0.369), and IL6(p<0.05; r=0.333)However, no correlations were noted between atherogenic indexes and IL7, IL17, IL23, TNFalpha.Conclusion:Our study showed a correlations between atherogenic indexes and both IL1 and IL6.These findings suggests that serum IL-6 and IL1 levels in spondyloarthritis contribute to the development of cardiovascular disease atherosclerosis.