AB0692 CLINICAL SIGNIFICANCE OF LIPID PROFILES IN PATIENTS WITH AXIAL SPONDYLOARTHRITIS

Abstract

Background:Axial spondyloarthritis (axSpA) is a chronic inflammatory disease of the sacroiliac joints and spine. Lipid profiles, including total cholesterol(TC), high-density lipoprotein cholesterol(HDL-c), low-density lipoprotein cholesterol (LDL-c), TC/HDL-c, triglycerides(TG), have been reported to be changed regularly in axSpA patients. However, the clinical significance of lipid profiles in axSpA patients is controversial.Objectives:The study aims to determine the clinical significance of TC, HDL-c, LDL-c, TC/HDL-c, TG for axSpA patients.Methods:A total of 208 axSpA patients and 113 healthy subjects were enrolled in the study retrospectively. TC, HDL-c, LDL-c, TC/HDL-c, TG, C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), Bath Ankylosing Spondylitis Disease Activity Index(BASDAI) were collected. AxSpA patients were divided into remission axSpA group(BASDAI<4, n=123) and active axSpA group(BASDAI≥4, n=85). Relationships between the parameters were assessed by the Sperman’ s correlations analysis. Receiver operation characteristic (ROC) curves were used to discriminate axSpA patients from healthy subjects and active axSpA group from remission axSpA group.Results:TC, HDL-c, and TG in axSpA group were lower than those of control group, while TC/HDL-c was higher (P<0.05). ROC curve results showed that the AUC value of HDL-c for axSpA was 0.790 (CI95%: 0.740-0.839), yielding a highest AUC value. The optimal cutoff value of HDL-c for axSpA was 1.095, with the Youden index of 0.496, sensitivity of 65.5% and specificity of 84.1%. HDL-c was negatively correlated with BASDAI (r=-0.159, P=0.022). TC/HDL-c was positively correlated with BASDAI (r=0.183, P=0.008). Besides, TC/HDL-c, CRP, ESR in active axSpA group were higher than those of remission axSpA group, while HDL-c was lower (P<0.05). ROC curve results showed that the AUC value of TC/HDL-c and CRP for active axSpA group were 0.621 (CI95%: 0.543-0.700) and 0.634 (CI95%: 0.556-0.712), yielding a higher AUC value than other parameters. The optimal cutoff value of TC/HDL-c for active axSpA group was 4.429, with the Youden index of 0.201, sensitivity of 40.2% and specificity of 79.9%.Conclusion:HDL-c was decreased in axSpA patients with a highest diagnostic value, compared with healthy control. TC/HDL-c was elevated in active axSpA patients, showing a significant correlation to the disease activity of axSpA.