A1340 Elevated circulating Homocysteine and High Sensitivity C-Reactive Protein jointly as Useful Predictive Factors for Arterial Stiffness

Abstract

Objectives: Elevated plasma total homocysteine (tHcy) and high sensitivity C-reactive protein (hsCRP) levels are independent risk factors for cardiovascular disease. This study aimed to evaluate the effectiveness of tHcy and hsCRP as potential markers for arterial stiffness in Chinese adults. Methods: we conducted a 12-year longitudinal study in 220 individuals in Hanzhong, China from 2005 to 2017. The average age at follow-up was 41.83 ± 3.10 years old. Demographic information, medical history, blood pressure, and anthropometric measurements as well as fasting blood and urine samples, including tHcy, hsCRP and brachial-ankle pause wave velocity (baPWV) were measured and analyzed. Results: We found that subjects whose baseline tHcy and hsCRP levels were above 75th percentile were prone to be at the highest quartile at follow-up (tHcy: RR:9.649; 95% CI, 4.206–22.137; P < 0.01; hsCRP: RR:3.601; 95% CI, 1.599–8.109; P < 0.01). The risk of developing arterial stiffness was significantly increased in the highest quartile of baseline hsCRP, while the associations were not found between baseline tHcy and follow-up baPWV. Besides when tHcy and hsCRP were combined, compared with low tHcy/low hsCRP (tHcy < 12.3 μmol/L and hsCRP < 0.36 μmol/L), high tHcy or/and high hsCRP was/were significantly associated with elevated risk for developing arterial stiffness (baPWV≥12 m/s) after adjusting for confounders in logistic regression models. Conclusion: The combination of plasma tHcy and hsCRP level has a strong predictive value for arterial stiffness.