A Vision for Treating Alzheimer's Disease

Abstract

Ais a type of amyloid that is the main component of the senile plaques found in the brains of people with Alzheimer's disease. It is generally thought to be associated with various neurodegenerative behaviors. At the same time, cellular autophagy disorders have also been observed in large numbers in Alzheimer's patients. However, due to technical obstacles, humans have not been very clear about the specific mechanism of Alzheimer's. Previously, the mainstream view has been that A causes autophagy disorder, which leads to Alzheimer's disease. However, emerging evidence points to the fact that A is actually a downstream event of autophagy disorder. In the experiment, they observed the specific process of autophagy in the brain by using a dual fluorescent labeling method and a variety of high-end imaging techniques at the same time. In addition, through this method, they also found that A accumulates in the cell in the early stage of the disease, rather than outside the cell as we generally think. So our goal should also shift from A removal to how to prevent autophagy disorder. While describing this situation, this paper also proposes some possible methods that have been discovered so far to prevent autophagy disorders.