Abstract
A novel PtIV triazolato azido complex [3]-[N1,N3] has been synthesised via a strain-promoted double-click reaction (SPDC) between a PtIV azido complex (1) and the Sondheimer diyne (2). Photoactivation of [3]-[N1,N3] with visible light (452 nm) in the presence of 5'-guanosine monophosphate (5'-GMP) produced both PtIV and PtII 5'-GMP species; EPR spectroscopy confirmed the production of both azidyl and hydroxyl radicals. Spin-trapping of photogenerated radicals - particularly hydroxyl radicals - was significantly reduced in the presence of 5'-GMP.
Highlights
A novel PtIV triazolato azido complex [3]-[N1,N3] has been synthesised via a strain-promoted double-click reaction (SPDC) between a PtIV azido complex (1) and the Sondheimer diyne (2)
Photoactivation of [3]-[N1,N3] with visible light (452 nm) in the presence of 50-guanosine monophosphate (50-GMP) produced both PtIV and PtII 50-GMP species; EPR spectroscopy confirmed the production of both azidyl and hydroxyl radicals
We recently reported the first PtIV triazolato monoazido complexes; synthesised via click reactions of PtIV
Summary
A novel PtIV triazolato azido complex [3]-[N1,N3] has been synthesised via a strain-promoted double-click reaction (SPDC) between a PtIV azido complex (1) and the Sondheimer diyne (2). Photoactivation of [3]-[N1,N3] with visible light (452 nm) in the presence of 50-guanosine monophosphate (50-GMP) produced both PtIV and PtII 50-GMP species; EPR spectroscopy confirmed the production of both azidyl and hydroxyl radicals.
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