Abstract
HeLa cells infected with adenovirus types 1, 2, 4, 5, and 6 produce a factor which inhibits multiplication of adenovirus type 5, poliovirus type 1, and vaccinia virus in HeLa cells. Its action on the multiplication of other adenovirus or poliovirus types was not investigated. Treatment of HeLa cells with this inhibitor for varying periods before infection causes a progressive and proportional reduction in (1) complement-fixing antigen production, (2) the proportion of cells showing cytopathic effect, and (3) the proportion of cells yielding virus. These effects are apparently not due to inhibition of virus adsorption. The inhibitor is neutralized type-specifically by adenovirus antisera. Its activity is associated with the type-specific component shared by adenovirus-antigens B and C. It is distinct from interferon.
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