Abstract
A versatile tumor‐targeting stimuli‐responsive theranostic platform for peritoneal metastases of colorectal cancer is proposed in this work for tumor tracking and photothermal‐enhanced chemotherapy. A quenched photosensitizer (“off” state) is developed and escorted into a tumor‐targeting oxaliplatin‐embedded micelle. Once reaching the tumor cell, the micelle is clasped to release free oxaliplatin, as well as the “off” photosensitizer, which is further activated (“turned‐on”) in the tumor reducing microenvironment to provide optical imaging and photothermal effect. The combined results from hyperthermia‐enhanced chemotherapy, deep penetration, perfused O2, and the leveraged GSH‐ROS imbalance in tumor cells are achieved for improved antitumor efficacy and reduced systematic toxicity.
Highlights
A versatile tumor-targeting stimuli-responsive theranostic platform for every year.[1] 25% of colorectal cancer patients will experience peritoneal metastases peritoneal metastases of colorectal cancer is proposed in this work for tumor (CCPM) due to its natural of serosa intracking and photothermal-enhanced chemotherapy
The hyperthermia further exacerbates the damage to healthy tissues. 95% of CCPM patients post hyperthermic intraperitoneal chemotherapy (HIPEC) were found with strong adverse reactions, including renal-/hepato/gastrointestinal-toxicity and myelosuppression.[7]
The dinitrobenzene sulfonate group can act as a recognizing moiety to thiolcontaining spices which are at high levels in tumor cells
Summary
A versatile tumor-targeting stimuli-responsive theranostic platform for every year.[1] 25% of colorectal cancer patients will experience peritoneal metastases peritoneal metastases of colorectal cancer is proposed in this work for tumor (CCPM) due to its natural of serosa intracking and photothermal-enhanced chemotherapy. A quenched photosensitizer (“off” state) is developed and escorted into a tumor-targeting oxaliplatin-embedded micelle. Once reaching the tumor cell, the micelle is clasped to release free oxaliplatin, as well as the “off” photosensitizer, which filtration, with a 5-year survival rate less than 10% in clinic.[2] CCPM, which is multiple and scattered, is the terminal stage of colorectal cancer, and the therapy is extremely difficult. Hyperthermia-enhanced chemotherapy, deep penetration, perfused O2, and the leveraged GSH-ROS imbalance in tumor cells are achieved for improved antitumor efficacy and reduced systematic toxicity. The gold standard treatment is hyperthermic intraperitoneal chemotherapy (HIPEC),[4] which indicates a continuous perfused intraperitoneal circulation of heated chemotherapy fluid (≈43 °C) for
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