Study of tumor markers combined with clinicopathological diagnosis for prejudgement of peritoneal metastasis of colorectal cancer

Abstract

Objective To explore the significance of serum CEA、CA19-9 and CA125 levels combined with clinicopathological diagnosis for preoperative diagnosis of peritoneum metastasis of colorectal cancer. Methods A total of 1 215 patients with colorectal cancer and rectal cancer located above the rectum and peritoneum were collected from the Colorectal Cancer Institute of the Harbin Medical University from January 2014 to October 2017, including 988 patients without peritoneal metastasis and 227 patients with synchronous peritoneal metastasis, and a retrospective analysis was carried out to compare the clinical data of two groups. Results The incidence of peritoneal metastasis in highly differentiated adenocarcinoma, moderately differentiated adenocarcinoma, low differentiated adenocarcinoma, mucous adenocarcinoma, and signet ring cell cancer was 0, 5.4%.35.6%, 45.3%, 75%, the higher the degree of pathological malignancy, the more prone to peritoneum metastasis. CA125 is the most sensitive in the diagnosis of peritoneal metastasis of colorectal cancer in the three cases of serum CEA, CA19-9 and CA125, it is 100%, area under curve is 0.897, both of them were significantly higher than the other two (CEA, CA19-9). The specificity was close to CEA, lower than CA19-9, the specificity of CA19-9 was the highest (86%), but sensitivity (47%) and area under the curve (0.669) were the lowest. The greater the increase of CEA, CA19-9 and CA125, the greater the probability of peritoneal metastasis. When CEA+ CA125 increased or CA125+ CA19-9 increased or CEA+ CA125+ CA19-9 increased, the probability of peritoneal metastasis was 65.7%, 73.1% and 77.3%, respectively. Conclusion The accuracy of preoperative diagnosis of peritoneal metastasis of colorectal cancer can be improved by CEA, CA19-9 and CA125 combined with clinical pathology examination. It is helpful to predict the prognosis and prognosis of patients with colorectal cancer. Key words: Colorectal neoplasms; Surgical procedures, operative; CEA; CA19-9; CA125; Peritoneal metastasis