Abstract
Among the various scaffold fabrication techniques, thermally induced phase separation (TIPS) is one of the most versatile methods to produce porous polymeric scaffold and it has been largely used for its capability to produce highly porous and interconnected scaffolds. The scaffold architecture can be closely controlled by varying the process parameters, including polymer type and concentration, solvent/non-solvent ratio and thermal history. TIPS technique has been widely employed, also, to produce scaffolds with a hierarchical pore structure and composite polymeric matrix/inorganic filler foams.
Highlights
The so-called scaffold is one of the building blocks of the tissue engineering approach; the design of a scaffold includes the selection of its constitutive material, its design architecture and often the surface and/or bulk treatment(s) [1]
By taking advantage of the thermally induced phase separation (TIPS) process, since the pore dimension is mainly dependent on the residence time in the metastable region [23], Mannella et al [24] proposed an experimental apparatus able to impose a different T vs. time pathway on two sides of a sample
In this way a gradient of pore dimension was obtained along the scaffold thickness in a single step, without requiring the junction of the multiple layers
Summary
Received Date: May 19, 2017; Accepted Date: May 25, 2017; Published Date: June 01, 2017
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